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DSS-induced colitis in mice elicited pronounced symptoms, including reduced locomotor activity, decreased consumption of food and water, dull and lifeless fur, signs of depression-like behavior, huddling behavior, perianal swelling and congestion, diarrhea, bloody stools, and substantial weight loss

G., Wallace, T

In addition, since the known effect of oxidative stress in MDD pathophysiology and the frequent MDD comorbidity in OCD may be a confounding factor in our data, we aimed to compare OCD patients with and without MDD comorbidity within themselves and with healthy controls in this study

The liver produces glutathione